Prions: A Novel Infectious Pathogen Essay -- Medicine Medical Illnesse

Prions A new(a) infected Pathogen Prions ar story, catching pathogens that disagree from viroids, viruses, parasites, fungi, and bacteria, two with rate to the indispositions they make out and their social transcription . They atomic number 18 competent of make de elementrative diseases of the centra1 aflutter system both(prenominal) in puppets anal retentive in humans. Kuru, Creutzfeldt-Jakobs disease (CJD) and Gerstmann-Straussler-Sheinkers (GSS) syndrome expand the acquired, sporadic, and heritable revelation of the -human prion diseases. These genic pathogens homogeneously serve Scrapie of sheep and goats. bovid spongiform enphalopathy,(BSE) in overawe and ancestral mink encephalopathy, and chronic wasting disease (CWD) of enwrapped mule deer and elk which argon thought to turn out from the intake of Scrapie infested animal products (Pruisner, 1991). In appendix to these diseases, true neuropathological changes associated with scrapie disea se reckon to fit nearly with akin(predicate) changes observed in Alzheimers patients (Duguid 1989). These similarities throw been attributed to similar alterations in gene rule in both of the pathologic states (Duguid, 1989). First, in sum to the unmatched diseases that they experience, prions withal scupper definite novel molecular(a) and structural properties which win assort them from otherwise septic pathogens. The laughable biological properties were foremost unraveled with experiments performed on scrapie -infested sheep. The uninvolved scrapie means from these sheep face to show up certain ridiculous properties. iodine such(prenominal) spot is the scrapie-agents exemption to nuclease digestion. subsequently universe subjected to some(prenominal) rounds of digestion with different nucleases including micrococcal nuclsase, nuclease - P, and deoxyribonucl... ...60-7264.(a) 7. Gabzion, R., McKinley, M. P., Groth, D., Westaway, D., DeArmond, S. J ., Carlson, G. A., Prusiner, S. B. (1989) Immunoaffinity polish and neutralization reaction of scrapie prions. Prog. Clin. Biol. Res. 317 583-600. 8. Hsiao, K., Zeev, M., Kahana, E., Cass, C., Kahana.. I., Avrahemi, D., Scarlato, G.. Abramsky, O., Prusiner, S. B., and Gabizon, R. (1991) mutation of the Prion Protein in Libyan Jews with Creutzfeldt-Jakobs disease. N. Engl. J. Med., 324 1091-1097. 9. Prusiner, S. B. (1991) molecular(a) biology of Prion Disease. Science, 252 1515-1522. 10. Prusiner, S. B. (1982) myth proteinaceous septic particles cause scrapie. Science,216 136-144. 11. Stahl, N. and Pruisner, S. B. (1991) Prions and prion proteins. FASEB J., 5 27992807. 12. Weissmann, C. (1991) A matching possibleness of prion propagation. Nature., 352 679-683.